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Issue 78, 2019
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Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

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Abstract

Here we show trapping of chiral enolates with carbenium ions, Michael acceptors, and bromine. Silyl ketene aminals, disilyl acetals, and aza-enolates were obtained via Lewis acid mediated enantioselective conjugate addition of Grignard reagents to unsaturated amides, carboxylic acids and alkenyl heterocycles.

Graphical abstract: Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

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Publication details

The article was received on 02 Jul 2019, accepted on 05 Sep 2019 and first published on 05 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05041H
Chem. Commun., 2019,55, 11766-11769

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    Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

    D. Vargová, J. M. Pérez, S. R. Harutyunyan and R. Šebesta, Chem. Commun., 2019, 55, 11766
    DOI: 10.1039/C9CC05041H

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