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Issue 78, 2019
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Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

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Abstract

Here we show trapping of chiral enolates with carbenium ions, Michael acceptors, and bromine. Silyl ketene aminals, disilyl acetals, and aza-enolates were obtained via Lewis acid mediated enantioselective conjugate addition of Grignard reagents to unsaturated amides, carboxylic acids and alkenyl heterocycles.

Graphical abstract: Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

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Article information


Submitted
02 Jul 2019
Accepted
05 Sep 2019
First published
05 Sep 2019

Chem. Commun., 2019,55, 11766-11769
Article type
Communication

Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

D. Vargová, J. M. Pérez, S. R. Harutyunyan and R. Šebesta, Chem. Commun., 2019, 55, 11766
DOI: 10.1039/C9CC05041H

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