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Isotopic core–satellites enable accurate and sensitive bioassay of adenosine triphosphate

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Abstract

Adenosine triphosphate is a major vector of chemical energy in living organisms, but its detection is sometimes hindered by complicated physiological sample matrixes. In this work, we demonstrated a ratiometric bioassay for the accurate and sensitive detection of ATP by measuring the 197Au/115In signal ratio of a mass spectrometric core–satellite structure. Validation of the proposed bioassay was successfully demonstrated in cell lysates and human serum samples.

Graphical abstract: Isotopic core–satellites enable accurate and sensitive bioassay of adenosine triphosphate

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Publication details

The article was received on 29 Jun 2019, accepted on 05 Aug 2019 and first published on 06 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04988F
Chem. Commun., 2019, Advance Article

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    Isotopic core–satellites enable accurate and sensitive bioassay of adenosine triphosphate

    C. Wang, X. Zhao, R. Liu, Z. Zhong, J. Hu and Y. Lv, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04988F

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