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Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

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Abstract

RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA.

Graphical abstract: Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

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Publication details

The article was received on 26 Jun 2019, accepted on 08 Aug 2019 and first published on 09 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04915K
Chem. Commun., 2019, Advance Article

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    Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

    J. Joly, M. Gaysinski, L. Zara, M. Duca and R. Benhida, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04915K

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