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Issue 70, 2019
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Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

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Abstract

RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA.

Graphical abstract: Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

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Article information


Submitted
26 Jun 2019
Accepted
08 Aug 2019
First published
09 Aug 2019

Chem. Commun., 2019,55, 10432-10435
Article type
Communication

Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

J. Joly, M. Gaysinski, L. Zara, M. Duca and R. Benhida, Chem. Commun., 2019, 55, 10432
DOI: 10.1039/C9CC04915K

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