Issue 69, 2019
From the journal:

Chemical Communications

Integrated magneto-fluorescence nanobeads for ultrasensitive glycoprotein detection using antibody coupled boronate-affinity recognition†

Jing Chen,ab   Liangwen Hao,ab   Yunqing Wu,ab   Tong Lin,ab   Xiangmin Li,c   Yuankui Leng, ORCID logo ab   Xiaolin Huang ORCID logo *ab  and  Yonghua Xiong ORCID logo *abc  

* Corresponding authors

a State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
E-mail: hxl19880503@163.com, yhxiongchen@163.com

b School of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China

c Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China

Abstract

Herein, we report a novel magnet-mediated antibody-boronate sandwich-typed assay (ABSTA) strategy for the ultrasensitive, specific, rapid, and enzyme-free detection of glycoproteins in complex samples. The proposed ABSTA method exhibited ultrahigh sensitivity for HCG with a detection limit of 0.19 mIU mL−1, which is approximately 40-fold lower than that of conventional sandwich enzyme immunoassay.

Graphical abstract: Integrated magneto-fluorescence nanobeads for ultrasensitive glycoprotein detection using antibody coupled boronate-affinity recognition

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Article information

DOI
https://doi.org/10.1039/C9CC04902A
Article type
Communication
Submitted
26 Jun 2019
Accepted
05 Aug 2019
First published
06 Aug 2019

Chem. Commun., 2019,55, 10312-10315

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Integrated magneto-fluorescence nanobeads for ultrasensitive glycoprotein detection using antibody coupled boronate-affinity recognition

J. Chen, L. Hao, Y. Wu, T. Lin, X. Li, Y. Leng, X. Huang and Y. Xiong, Chem. Commun., 2019, 55, 10312 DOI: 10.1039/C9CC04902A

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