We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in terms of immunogenicity and cellular uptake.
The article was received on 25 Jun 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019
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