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Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors

Abstract

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in terms of immunogenicity and cellular uptake.

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Supplementary files

Publication details

The article was received on 25 Jun 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019


Article type: Communication
DOI: 10.1039/C9CC04872C
Chem. Commun., 2019, Accepted Manuscript

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    Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors

    Y. Kimura, Z. Shu, M. Ito, N. Abe, K. Nakamoto, F. Tomoike, S. Shuto, Y. Ito and H. Abe, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC04872C

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