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Abstract | Cited by

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.

Graphical abstract: Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

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