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A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

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Abstract

A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize 1O2 generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.

Graphical abstract: A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

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Publication details

The article was received on 25 Jun 2019, accepted on 05 Aug 2019 and first published on 05 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04871E
Chem. Commun., 2019, Advance Article

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    A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

    L. He, M. Zhang, Z. Pan, K. Wang, Z. Zhao, Y. Li and Z. Mao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04871E

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