Issue 76, 2019
From the journal:

Chemical Communications

Simple and robust polymer-based sensor for rapid cancer detection using serum†

Ngoc D. B. Le,a   Arvind K. Singla,b   Yingying Geng,a   Jinsong Han,c   Kai Seehafer,c   Gyan Prakash,a   Daniel F. Moyano,a   Charlene M. Downey,b   Michael J. Monument,d   Doha Itani,e   Uwe H. F. Bunz, ORCID logo c   Frank R. Jirikb  and  Vincent M. Rotello ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA
E-mail: rotello@chem.umass.edu

b Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada

c Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany

d Department of Surgery, The McCaig Institute for Bone and Joint Health, Arnie Charbonneau Cancer Institute, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada

e Department of Pathology and Laboratory Medicine, Calgary Laboratory Services/University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada

Abstract

We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.

Graphical abstract: Simple and robust polymer-based sensor for rapid cancer detection using serum

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Article information

DOI
https://doi.org/10.1039/C9CC04854E
Article type
Communication
Submitted
11 Jul 2019
Accepted
02 Sep 2019
First published
02 Sep 2019

Chem. Commun., 2019,55, 11458-11461

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Simple and robust polymer-based sensor for rapid cancer detection using serum

N. D. B. Le, A. K. Singla, Y. Geng, J. Han, K. Seehafer, G. Prakash, D. F. Moyano, C. M. Downey, M. J. Monument, D. Itani, U. H. F. Bunz, F. R. Jirik and V. M. Rotello, Chem. Commun., 2019, 55, 11458 DOI: 10.1039/C9CC04854E

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