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A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions

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Abstract

An indicator displacement assay (IDA) was used to probe phosphate ions in an aqueous medium at neutral pH using a dinuclear cerium based complex [Ce2(HXTA)]3+. The homoleptic complex can be used to detect phosphate ions with nanomolar affinity either spectrophotometrically or with the naked-eye. To our knowledge, this is the first dinuclear cerium biomimetic IDA detection system with the highest affinity known to date for selective, naked-eye based phosphate recognition under physiological conditions (pH = 5–7) and even in pure water and complex samples such as sea water.

Graphical abstract: A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions

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Publication details

The article was received on 25 Jun 2019, accepted on 31 Oct 2019 and first published on 31 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC04840E
Chem. Commun., 2019, Advance Article

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    A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions

    T. Rossel and M. Creus, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04840E

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