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Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes

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Abstract

We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.

Graphical abstract: Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes

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Publication details

The article was received on 20 Jun 2019, accepted on 23 Sep 2019 and first published on 27 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC04751D
Chem. Commun., 2019, Advance Article

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    Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes

    K. Basnet, T. Fatemipouya, A. St. Lorenz, M. Nguyen, O. Taratula, M. Henary and K. B. Grant, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04751D

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