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Dual function of carbon tetrachloride: synthesis of chlorinated heterocycles

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Abstract

An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

Graphical abstract: Dual function of carbon tetrachloride: synthesis of chlorinated heterocycles

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Publication details

The article was received on 20 Jun 2019, accepted on 09 Aug 2019 and first published on 12 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04746H
Chem. Commun., 2019, Advance Article

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    Dual function of carbon tetrachloride: synthesis of chlorinated heterocycles

    S. Kumar, R. K. Saunthwal, K. M. Saini and A. K. Verma, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04746H

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