Shiv Kumar, Rakesh K. Saunthwal, Kapil M. Saini and Akhilesh K. Verma
Chem. Commun., 2019,55, 10721-10724
DOI:
10.1039/C9CC04746H,
Communication
An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.
