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Issue 71, 2019

P4T-DOTA – a lanthanide chelating tag combining a sterically highly overcrowded backbone with a reductively stable linker

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Abstract

Herein we report a DOTA-based lanthanide chelating tag (LCT) with rigidified backbone and a reduction-stable linker. The newly developed tag induces strong pseudocontact shifts suitable for paramagnetic protein nuclear magnetic resonance spectroscopy and the obtained anisotropic susceptibility parameters are in the range of the best performing LCTs.

Graphical abstract: P4T-DOTA – a lanthanide chelating tag combining a sterically highly overcrowded backbone with a reductively stable linker

Supplementary files

Article information


Submitted
18 Jun 2019
Accepted
08 Aug 2019
First published
09 Aug 2019

This article is Open Access

Chem. Commun., 2019,55, 10543-10546
Article type
Communication

P4T-DOTA – a lanthanide chelating tag combining a sterically highly overcrowded backbone with a reductively stable linker

D. Joss and D. Häussinger, Chem. Commun., 2019, 55, 10543 DOI: 10.1039/C9CC04676C

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