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Issue 62, 2019
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Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

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Abstract

We constructed GFP-encapsulated microtubules (MTs) using a Tau-derived peptide which binds to their interior. The encapsulation of the GFP dramatically increased the rigidity of MTs, resulting in their enhanced velocity on a kinesin-coated substrate. Moreover, the GFP-encapsulated MTs were significantly more stable than normal MTs.

Graphical abstract: Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

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Supplementary files

Article information


Submitted
06 Jun 2019
Accepted
26 Jun 2019
First published
26 Jun 2019

Chem. Commun., 2019,55, 9072-9075
Article type
Communication

Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

H. Inaba, T. Yamamoto, T. Iwasaki, A. Md. R. Kabir, A. Kakugo, K. Sada and K. Matsuura, Chem. Commun., 2019, 55, 9072
DOI: 10.1039/C9CC04345D

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