A neutral water-soluble mitochondria-targeting polymer

Yu Geng; Yin Zhong; Quan Zhou; Siqin Chen; Ying Piao; Wei Yin; Hua Lu; Youqing Shen

doi:10.1039/C9CC04291A

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A neutral water-soluble mitochondria-targeting polymer†

Yu Geng,‡^a Yin Zhong,‡^a Quan Zhou,^a Siqin Chen,^a Ying Piao,^a Wei Yin,^b Hua Lu

^c and Youqing Shen

*^a

Author affiliations

* Corresponding authors

^a Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
E-mail: shenyq@zju.edu.cn

^b Facilities of the School of Medicine, Zhejiang University, Hangzhou, China

^c College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Abstract

We report the first neutral and water-soluble polymer capable of strong mitochondrial targeting in vitro and in vivo, zwitterionic poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA). OPDEA is quickly internalized via macropinocytosis by various cancer cells and transferred into the mitochondria, which slightly lowers the mitochondrial membrane potential as determined by the JC-1 assay.

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Article information

DOI: https://doi.org/10.1039/C9CC04291A
Article type: Communication
Submitted: 04 Jun 2019
Accepted: 22 Jul 2019
First published: 22 Jul 2019

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Chem. Commun., 2019,55, 10015-10018

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A neutral water-soluble mitochondria-targeting polymer

Y. Geng, Y. Zhong, Q. Zhou, S. Chen, Y. Piao, W. Yin, H. Lu and Y. Shen, Chem. Commun., 2019, 55, 10015 DOI: 10.1039/C9CC04291A

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Chemical Communications

A neutral water-soluble mitochondria-targeting polymer†

Abstract

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Article information

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A neutral water-soluble mitochondria-targeting polymer

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