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Issue 74, 2019
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An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro

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Abstract

Parkinson's disease (PD), closely associated with the misfolding and aggregation of the neuronal protein α-synuclein (A-Syn), is a neurodegenerative disorder with no cure to date. Here, we show that the commercially available, inexpensive, aminoglycoside antibiotic kanamycin effectively inhibits both lipid-induced and solution-phase aggregation of A-Syn in vitro, pointing towards the prospective repurposing of kanamycin as a potential anti-PD drug.

Graphical abstract: An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro

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Article information


Submitted
03 Jun 2019
Accepted
19 Aug 2019
First published
19 Aug 2019

Chem. Commun., 2019,55, 11052-11055
Article type
Communication

An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro

A. Mahapatra, S. Sarkar, S. C. Biswas and K. Chattopadhyay, Chem. Commun., 2019, 55, 11052
DOI: 10.1039/C9CC04251B

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