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A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

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Abstract

The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix.

Graphical abstract: A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

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Publication details

The article was received on 30 May 2019, accepted on 06 Aug 2019 and first published on 06 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04172A
Chem. Commun., 2019, Advance Article

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    A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

    H. R. Lim, S. Y. Kim, E. H. Jeon, Y. L. Kim, Y. M. Shin, T. Koo, S. J. Park, K. B. Hong and S. Choi, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC04172A

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