A nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H2S/NO crosstalk in biological systems

Mingwang Yang; Jiangli Fan; Wen Sun; Jianjun Du; Saran Long; Kun Shao; Xiaojun Peng

doi:10.1039/C9CC04060A

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A nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H₂S/NO crosstalk in biological systems†

Mingwang Yang,^a Jiangli Fan,

*^ab Wen Sun,

^ab Jianjun Du,

^ab Saran Long,^ab Kun Shao^ab and Xiaojun Peng

^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, P. R. China

^b Shenzhen Research Institute, Dalian University of Technology, Gaoxin South fourth Road, Nanshan District, Shenzhen 518057, P. R. China
E-mail: fanjl@dlut.edu.cn

Abstract

We present a near-infrared (NIR) fluorescent probe, NR-HNO, which was successfully applied to visualizing H₂S/NO “crosstalk” by the fluorescence detection of nitroxyl with a fast response time (5 min) and a large Stokes shift (131 nm) in living cells and tissue; it was also used to image nitroxyl in live mice.

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Article information

DOI: https://doi.org/10.1039/C9CC04060A
Article type: Communication
Submitted: 26 May 2019
Accepted: 24 Jun 2019
First published: 25 Jun 2019

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Chem. Commun., 2019,55, 8583-8586

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A nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H₂S/NO crosstalk in biological systems

M. Yang, J. Fan, W. Sun, J. Du, S. Long, K. Shao and X. Peng, Chem. Commun., 2019, 55, 8583 DOI: 10.1039/C9CC04060A

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Chemical Communications