Transient directing ligand- and solvent-controlled C–H/C–H cross-coupling/quaternization cyclization/dequaternization of benzaldehydes with thiophenes†
Abstract
Rh(III)-Catalyzed oxidative C–H/C–H cross-coupling between benzaldehydes and thiophenes has been accomplished for the first time. In such reactions, transient directing ligands (TDLs) can not only promote ortho-C–H activation, but can also control the chemoselectivity through a suitable combination of different solvents.