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Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

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Abstract

In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological activity in boron neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and apoptosis when irradiated with neutrons in an in vitro BNCT assay.

Graphical abstract: Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

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Publication details

The article was received on 21 May 2019, accepted on 18 Sep 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC03924D
Chem. Commun., 2019, Advance Article

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    Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

    I. Nakase, M. Katayama, Y. Hattori, M. Ishimura, S. Inaura, D. Fujiwara, T. Takatani-Nakase, I. Fujii, S. Futaki and M. Kirihata, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC03924D

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