Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

Ikuhiko Nakase; Miku Katayama; Yoshihide Hattori; Miki Ishimura; Shunsuke Inaura; Daisuke Fujiwara; Tomoka Takatani-Nakase; Ikuo Fujii; Shiroh Futaki; Mitsunori Kirihata

doi:10.1039/C9CC03924D

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)†

Ikuhiko Nakase,

*^ab Miku Katayama,^ab Yoshihide Hattori,

*^c Miki Ishimura,^c Shunsuke Inaura,^a Daisuke Fujiwara,^a Tomoka Takatani-Nakase,^d Ikuo Fujii,^a Shiroh Futaki^e and Mitsunori Kirihata

*^c

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* Corresponding authors

^a Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan
E-mail: i-nakase@21c.osakafu-u.ac.jp

^b NanoSquare Research Institute, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan

^c Research Center of BNCT, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan
E-mail: y0shi_hattori@riast.osakafu-u.ac.jp, kirihata@biochem.osakafu-u.ac.jp

^d Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan

^e Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan

Abstract

In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological activity in boron neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and apoptosis when irradiated with neutrons in an in vitro BNCT assay.

Chemical Communications

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)†

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Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

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