In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis

Hui Wang; Yixin Zhang; Yuyun Yang; Zixu He; Chuanchen Wu; Wei Zhang; Wen Zhang; Ju Liu; Ping Li; Bo Tang

doi:10.1039/C9CC03814K

In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis†

Hui Wang,‡^a Yixin Zhang,‡^a Yuyun Yang,^a Zixu He,^a Chuanchen Wu,^a Wei Zhang,^a Wen Zhang,^a Ju Liu,*^ab Ping Li*^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Institute of Biomedical Sciences, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China
E-mail: lip@sdnu.edu.cn, tangb@sdnu.edu.cn

^b Medical Research Center, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated to Shandong First Medical University, P. R. China
E-mail: ju.liu@sdu.edu.cn

Abstract

We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine deficiency.

Chemical Communications

In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis†

Abstract

Supplementary files

Article information

Download Citation

Permissions

In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis

Social activity

Search articles by author

Spotlight

Advertisements