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Issue 57, 2019
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Harnessing the reactivity of ortho-formyl-arylketones: base-promoted regiospecific synthesis of functionalized isoquinolines

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Abstract

An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[h] isoquinolines from easily accessible ortho-formyl-arylketones and aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl isoquinolines and bis-isoquinolines were easily attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance and applicability towards large scale synthesis are the advantageous features of this developed methodology.

Graphical abstract: Harnessing the reactivity of ortho-formyl-arylketones: base-promoted regiospecific synthesis of functionalized isoquinolines

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Publication details

The article was received on 13 May 2019, accepted on 21 Jun 2019 and first published on 21 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC03689J
Chem. Commun., 2019,55, 8278-8281

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    Harnessing the reactivity of ortho-formyl-arylketones: base-promoted regiospecific synthesis of functionalized isoquinolines

    P. K. Mishra, S. Verma, M. Kumar, A. Kumar and A. K. Verma, Chem. Commun., 2019, 55, 8278
    DOI: 10.1039/C9CC03689J

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