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A dual-site controlled ratiometric probe revealing the simultaneous down-regulation of pH in lysosomes and cytoplasm during autophagy

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Abstract

In this work, a unique dual-site controlled fluorescent probe was presented for the sensitive and concurrent detection of pH in the cytoplasm and lysosomes. With the probe, the simultaneous down-regulation of pH in the lysosomes and cytoplasm during autophagy has been successfully revealed for the first time.

Graphical abstract: A dual-site controlled ratiometric probe revealing the simultaneous down-regulation of pH in lysosomes and cytoplasm during autophagy

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Publication details

The article was received on 13 May 2019, accepted on 06 Aug 2019 and first published on 07 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC03679B
Chem. Commun., 2019, Advance Article

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    A dual-site controlled ratiometric probe revealing the simultaneous down-regulation of pH in lysosomes and cytoplasm during autophagy

    M. Tian, C. Liu, B. Dong, Y. Zuo and W. Lin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC03679B

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