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Bridged α-helix mimetic small-molecules


Herein, we report a strategy for generating conformationally restricted α-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of α-helix mimetics. We demonstrate that the bridged α-helix mimetics have enhanced binding affinity and specificity to the target protein due to restricted conformation as well as extra interaction of the bridge with protein surface.

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Publication details

The article was received on 10 May 2019, accepted on 10 Oct 2019 and first published on 10 Oct 2019

Article type: Communication
DOI: 10.1039/C9CC03627J
Chem. Commun., 2019, Accepted Manuscript

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    Bridged α-helix mimetic small-molecules

    Y. Lee, H. Im, S. Das, M. Oh, J. H. Lee, S. Ham and H. Lim, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC03627J

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