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Issue 68, 2019
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Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer

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Abstract

Population-based screening of stage 0–I lung cancer is crucial to save lives. In this article, we describe the development of a method for the detection of a CYFRA 21-1-autoantibody complex and CYFRA 21-1 in plasma samples. The CIC/CYFRA 21-1 ratio allows the detection of stage I–IV lung cancer with 76.0% sensitivity and 87.5% specificity.

Graphical abstract: Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer

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Publication details

The article was received on 10 May 2019, accepted on 05 Jun 2019 and first published on 22 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC03620B
Chem. Commun., 2019,55, 10060-10063
  • Open access: Creative Commons BY-NC license
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    Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer

    K. Song, S. B. Nimse, S. D. Warkad, A. Oh, T. Kim and Y. J. Hong, Chem. Commun., 2019, 55, 10060
    DOI: 10.1039/C9CC03620B

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