Issue 72, 2019
From the journal:

Chemical Communications

Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates†

Oleksii Zozulia, ORCID logo ‡a   Tobias Bachmann,a   Nina S. Deussner-Helfmann,b   Frank Beierlein,c   Mike Heilemannb  and  Andriy Mokhir ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany
E-mail: Andriy.Mokhir@fau.de

b Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University, 60438 Frankfurt, Germany

c Computer-Chemistry-Center and Interdisciplinary Center for Molecular Materials, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany

Abstract

A red light-triggered reaction based on cyclic oligonucleotide substrates that is accelerated over 30-fold by specific nucleic acid templates and generates a bright fluorescent probe was developed. We confirmed that this reaction is compatible with fluorescence correlation spectroscopy (FCS) thereby allowing detection of nucleic acids down to 1 nM.

Graphical abstract: Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates

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Article information

DOI
https://doi.org/10.1039/C9CC03587G
Article type
Communication
Submitted
09 May 2019
Accepted
12 Aug 2019
First published
12 Aug 2019

Chem. Commun., 2019,55, 10713-10716

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Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates

O. Zozulia, T. Bachmann, N. S. Deussner-Helfmann, F. Beierlein, M. Heilemann and A. Mokhir, Chem. Commun., 2019, 55, 10713 DOI: 10.1039/C9CC03587G

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