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Issue 72, 2019
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Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates

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Abstract

A red light-triggered reaction based on cyclic oligonucleotide substrates that is accelerated over 30-fold by specific nucleic acid templates and generates a bright fluorescent probe was developed. We confirmed that this reaction is compatible with fluorescence correlation spectroscopy (FCS) thereby allowing detection of nucleic acids down to 1 nM.

Graphical abstract: Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates

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Article information


Submitted
09 May 2019
Accepted
12 Aug 2019
First published
12 Aug 2019

Chem. Commun., 2019,55, 10713-10716
Article type
Communication

Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates

O. Zozulia, T. Bachmann, N. S. Deussner-Helfmann, F. Beierlein, M. Heilemann and A. Mokhir, Chem. Commun., 2019, 55, 10713
DOI: 10.1039/C9CC03587G

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