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Issue 59, 2019
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Water gated contrast switching with polymer–silica hybrid nanoparticles

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Abstract

Bioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a large amplitude switch in a manner relevant to environmentally responsive imaging.

Graphical abstract: Water gated contrast switching with polymer–silica hybrid nanoparticles

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Publication details

The article was received on 29 Apr 2019, accepted on 02 Jul 2019 and first published on 02 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC03312B
Chem. Commun., 2019,55, 8540-8543

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    Water gated contrast switching with polymer–silica hybrid nanoparticles

    J. Pellico, C. M. Ellis, J. Miller and J. J. Davis, Chem. Commun., 2019, 55, 8540
    DOI: 10.1039/C9CC03312B

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