Issue 48, 2019
From the journal:

Chemical Communications

A fluorogenic BODIPY molecular rotor as an apoptosis marker†

Pichandi Ashokkumar, ORCID logo ‡a   Anila Hoskere Ashoka,‡ab   Mayeul Collot, ORCID logo *a   Amitava Das ORCID logo *c  and  Andrey S. Klymchenko ORCID logo *a  

* Corresponding authors

a Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, Strasbourg CS 60024, France
E-mail: andrey.klymchenko@unistra.fr, mayeul.collot@unistra.fr

b CSIR-National Chemical Laboratory, Pune 411008, India

c CSIR-Central Salt & Marine Chemicals Research Institute, Bhavnagar 364002, Gujarat, India
E-mail: a.das@csmcri.res.in

Abstract

Based on a BODIPY molecular rotor and a zinc–dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.

Graphical abstract: A fluorogenic BODIPY molecular rotor as an apoptosis marker

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Article information

DOI
https://doi.org/10.1039/C9CC03242H
Article type
Communication
Submitted
26 Apr 2019
Accepted
15 May 2019
First published
15 May 2019

Chem. Commun., 2019,55, 6902-6905

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A fluorogenic BODIPY molecular rotor as an apoptosis marker

P. Ashokkumar, A. H. Ashoka, M. Collot, A. Das and A. S. Klymchenko, Chem. Commun., 2019, 55, 6902 DOI: 10.1039/C9CC03242H

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