Bioconjugated arylpalladium complexes on solid supports for a convenient last-step synthesis of 11C-labelled tracers for positron emission tomography

Abstract

Arylpalladium complexes prepared from o-iodobenzylalcohol–biomolecule conjugates and triphenylphosphine linked on polystyrene beads provided convenient supported and stable precursors. These heterogeneous substrates could react smoothly with [¹¹C]CO, affording the corresponding ¹¹C-labelled bioconjugates with isolated radiochemical yields ranging from 4% to 71%, and excellent radiochemical purities from 86% to >98% after a simple filtration. Thus, this method opens up a new pathway for an easier automation of Pd-catalysed syntheses of PET tracers.