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TMSOTf Mediated ‘5/6-endo-dig’ Reductive Hydroamination for the Stereoselective Synthesis of Pyrrolidine and Piperidine derivatives

Abstract

TMSOTf mediated 5/6-endo-dig reductive hydroamination cascade on internal alkynylamines gave an expedient, stereoselective access to pyrrolidine and piperidine derivatives. We also demonstrate that protecting group on nitrogen has profound effect on the reactivity as well as diastereoselectivity of reductive hydroamination cascade.

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Supplementary files

Publication details

The article was received on 22 Apr 2019, accepted on 17 May 2019 and first published on 17 May 2019


Article type: Communication
DOI: 10.1039/C9CC03127H
Chem. Commun., 2019, Accepted Manuscript

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    TMSOTf Mediated ‘5/6-endo-dig’ Reductive Hydroamination for the Stereoselective Synthesis of Pyrrolidine and Piperidine derivatives

    S. J. Gharpure, D. S. Vishwakarma and R. K. Patel, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC03127H

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