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Issue 46, 2019
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Integration of a photocleavable element into DNA nanoswitches

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Abstract

Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

Graphical abstract: Integration of a photocleavable element into DNA nanoswitches

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Publication details

The article was received on 19 Apr 2019, accepted on 14 May 2019 and first published on 22 May 2019


Article type: Communication
DOI: 10.1039/C9CC03069G
Chem. Commun., 2019,55, 6587-6590

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    Integration of a photocleavable element into DNA nanoswitches

    A. R. Chandrasekaran, J. Abraham Punnoose, V. Valsangkar, J. Sheng and K. Halvorsen, Chem. Commun., 2019, 55, 6587
    DOI: 10.1039/C9CC03069G

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