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Issue 50, 2019
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β-Galactosidase instructed supramolecular hydrogelation for selective identification and removal of senescent cells

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Abstract

The identification and removal of senescent cells is very important to improve human health and prolong life. In this study, we introduced a novel strategy of β-galactosidase (β-Gal) instructed peptide self-assembly to selectively form nanofibers and hydrogels in senescent cells. We demonstrated that the in situ formed nanofibers could alleviate endothelial cell senescence by reducing p53, p21, and p16INK4a expression levels. We also demonstrated that our strategy could selectively remove senescent endothelial cells by inducing cell apoptosis, with an increase in the BAX/BCL-2 ratio and caspase-3 expression. Our study reports the first example of enzyme-instructed self-assembly (EISA) by a sugar hydrolase, which may lead to the development of supramolecular nanomaterials for the diagnosis and treatment of many diseases, such as cancer, and for other applications, such as wound healing and senescence.

Graphical abstract: β-Galactosidase instructed supramolecular hydrogelation for selective identification and removal of senescent cells

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Supplementary files

Article information


Submitted
19 Apr 2019
Accepted
28 May 2019
First published
30 May 2019

Chem. Commun., 2019,55, 7175-7178
Article type
Communication

β-Galactosidase instructed supramolecular hydrogelation for selective identification and removal of senescent cells

T. Xu, Y. Cai, X. Zhong, L. Zhang, D. Zheng, Z. Gao, X. Pan, F. Wang, M. Chen and Z. Yang, Chem. Commun., 2019, 55, 7175
DOI: 10.1039/C9CC03056E

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