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Issue 60, 2019

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

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Abstract

New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.

Graphical abstract: Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

Supplementary files

Article information


Submitted
18 Apr 2019
Accepted
18 Jun 2019
First published
19 Jun 2019

Chem. Commun., 2019,55, 8868-8871
Article type
Communication

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

L. I. Pilkington, R. C. Deed, K. Parish-Virtue, C. Huang, M. E. Walker, V. Jiranek, D. Barker and B. Fedrizzi, Chem. Commun., 2019, 55, 8868 DOI: 10.1039/C9CC03020D

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