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A NIR-triggered gate-keeper of a supramolecular conjugated unimicelle with two-photon absorption for controlled drug release

Abstract

A nea-infrared (NIR) sensitive gated assembly of a supramolecular conjugated unimicelle based on a robust host-guest recognition between the β-cyclodextrin-grafted hyperbranched conjugated polymer and azobenzene-functionlized poly(ethylene glycol) was constructed. Utilized as a drug carrier, such a unimicelle exhibited a controlled drug release by NIR-triggered photoisomerization of azobenzene in cancer cells via a two-photon excited fluorescence resonance energy transfer (TP-FRET) approach, leading to an efficient cancer therapy.

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Supplementary files

Publication details

The article was received on 14 Apr 2019, accepted on 07 May 2019 and first published on 07 May 2019


Article type: Communication
DOI: 10.1039/C9CC02901J
Chem. Commun., 2019, Accepted Manuscript

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    A NIR-triggered gate-keeper of a supramolecular conjugated unimicelle with two-photon absorption for controlled drug release

    Y. Huang, L. Shen, D. Guo, W. Yasen, Y. Wu, Y. Su, D. Chen, F. qiu, D. Yan and X. Zhu, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC02901J

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