A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release

Yu Huang; Lingyue Shen; Dongbo Guo; Wumaier Yasen; Yan Wu; Yue Su; Dong Chen; Feng Qiu; Deyue Yan; Xinyuan Zhu

doi:10.1039/C9CC02901J

A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release†

Yu Huang,^ab Lingyue Shen,*^c Dongbo Guo,

^a Wumaier Yasen,^a Yan Wu,^a Yue Su,

^a Dong Chen,

^a Feng Qiu,

*^cd Deyue Yan

^a and Xinyuan Zhu

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, P. R. China
E-mail: xyzhu@sjtu.edu.cn

^b Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK

^c Department of Oral & Maxillofacial-Head & Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, P. R. China
E-mail: fengqiu@sit.edu.cn, sharyshen@qq.com

^d School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, P. R. China

Abstract

A near-infrared (NIR)-sensitive gated assembly of supramolecular conjugated unimicelles based on robust host–guest recognition between a β-cyclodextrin-grafted hyperbranched conjugated polymer and azobenzene-functionalized poly(ethylene glycol) was constructed. Utilized as a drug carrier, these unimicelles exhibited controlled drug release through the NIR-triggered photoisomerization of azobenzene in cancer cells via a two-photon excited fluorescence resonance energy transfer (TP-FRET) approach, leading to efficient cancer therapy.

Chemical Communications

A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release†

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A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release

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