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Issue 52, 2019
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Total synthesis and antimalarial activity of mortiamides A–D

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Abstract

Mortiamides A–D (1–4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A–D (1–4) on a solid support by concomitant cyclization/cleavage without any oligomerization side reactions, and overall yields up to 48%. We also report on the antiplasmodial activity of mortiamides A–D (1–4). We show that three out of the four tested mortiamides (A, B and D) have moderate antiplasmodial activity, while mortiamide D (4) exhibits low micromolar activity.

Graphical abstract: Total synthesis and antimalarial activity of mortiamides A–D

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Supplementary files

Article information


Submitted
15 Apr 2019
Accepted
18 May 2019
First published
20 May 2019

Chem. Commun., 2019,55, 7434-7437
Article type
Communication

Total synthesis and antimalarial activity of mortiamides A–D

C. Bérubé, D. Gagnon, A. Borgia, D. Richard and N. Voyer, Chem. Commun., 2019, 55, 7434
DOI: 10.1039/C9CC02864A

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