Jump to main content
Jump to site search

Issue 52, 2019
Previous Article Next Article

Total synthesis and antimalarial activity of mortiamides A–D

Author affiliations

Abstract

Mortiamides A–D (1–4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A–D (1–4) on a solid support by concomitant cyclization/cleavage without any oligomerization side reactions, and overall yields up to 48%. We also report on the antiplasmodial activity of mortiamides A–D (1–4). We show that three out of the four tested mortiamides (A, B and D) have moderate antiplasmodial activity, while mortiamide D (4) exhibits low micromolar activity.

Graphical abstract: Total synthesis and antimalarial activity of mortiamides A–D

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2019, accepted on 18 May 2019 and first published on 20 May 2019


Article type: Communication
DOI: 10.1039/C9CC02864A
Chem. Commun., 2019,55, 7434-7437

  •   Request permissions

    Total synthesis and antimalarial activity of mortiamides A–D

    C. Bérubé, D. Gagnon, A. Borgia, D. Richard and N. Voyer, Chem. Commun., 2019, 55, 7434
    DOI: 10.1039/C9CC02864A

Search articles by author

Spotlight

Advertisements