Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 60, 2019

Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Author affiliations

Abstract

Ru(II)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [Ru(TAP)3]2+ (TAP = 1,4,5,8-tetraazaphenanthrene).

Graphical abstract: Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Supplementary files

Article information


Submitted
12 Apr 2019
Accepted
17 May 2019
First published
17 May 2019

Chem. Commun., 2019,55, 8764-8767
Article type
Communication

Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

W. Vanderlinden, P. J. Kolbeck, W. Frederickx, S. F. Konrad, T. Nicolaus, C. Lampe, A. S. Urban, C. Moucheron and J. Lipfert, Chem. Commun., 2019, 55, 8764 DOI: 10.1039/C9CC02838B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements