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Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Abstract

Ru(II)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of Ru(TAP)32+ (TAP = 1,4,5,8-tetraazaphenanthrene).

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Publication details

The article was received on 12 Apr 2019, accepted on 17 May 2019 and first published on 17 May 2019


Article type: Communication
DOI: 10.1039/C9CC02838B
Chem. Commun., 2019, Accepted Manuscript

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    Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

    W. Vanderlinden, P. J. Kolbeck, W. Frederickx, S. F. Konrad, T. Nicolaus, C. Lampe, A. S. Urban, C. Moucheron and J. Lipfert, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC02838B

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