Viral Capsid-like Titania for Selective Enrichment of Phosphorylated Peptides
Viral capsid-like materials have been recognized as bionanotechnology platforms with great potential in controlled drug release, gene transfer and bioimaging. However, their functions still need to be optimized in such aspects as the efficient drug transfer and selective targeting. Herein, we report a simple alternative strategy to fabricate viral capsid-like titania (VCL-TiO2) bearing ordered mesoporous channels and protrusions on the surface. The morphology of the synthesized titania materials matched nearly perfectly the outer surface of the real viral capsid. In particular, the robust VCL-TiO2 exhibited high porosity and high degree of monodispersity in the particle size which makes them ideal for selectively and efficiently enriching phosphorylated peptides (PPs). Moreover, the microsized VCL-TiO2 could be easily collected and recycled through centrifugation.