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Issue 46, 2019
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Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

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Abstract

The X-ray crystal structure of F43Y/T67R myoglobin revealed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, which represents a novel post-translational modification of heme proteins. Moreover, with the feature of a distal His–Arg pair, the designed artificial enzyme exhibited a peroxidase activity comparable to that of native peroxidases, such as the most efficient horseradish peroxidase.

Graphical abstract: Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

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Publication details

The article was received on 08 Apr 2019, accepted on 15 May 2019 and first published on 15 May 2019


Article type: Communication
DOI: 10.1039/C9CC02714A
Chem. Commun., 2019,55, 6610-6613

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    Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

    C. Liu, H. Yuan, F. Liao, C. Wei, K. Du, S. Gao, X. Tan and Y. Lin, Chem. Commun., 2019, 55, 6610
    DOI: 10.1039/C9CC02714A

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