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A DNAzyme-powered cross-catalytic circuit for amplified intracellular imaging

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Abstract

A facile cross-catalytic circuit is engineered for intracellular microRNA (miRNA) imaging by facilely integrating a catalytic hairpin assembly (CHA) amplifier and DNAzyme biocatalyst through an ingenious feedback loop. These two indispensable catalytic reactions play vital roles in executing high-performance signal amplification, as demonstrated experimentally and theoretically.

Graphical abstract: A DNAzyme-powered cross-catalytic circuit for amplified intracellular imaging

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Publication details

The article was received on 04 Apr 2019, accepted on 08 May 2019 and first published on 09 May 2019


Article type: Communication
DOI: 10.1039/C9CC02637A
Chem. Commun., 2019, Advance Article

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    A DNAzyme-powered cross-catalytic circuit for amplified intracellular imaging

    L. Zou, Q. Wu, Y. Zhou, X. Gong, X. Liu and F. Wang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02637A

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