Issue 43, 2019
From the journal:

Chemical Communications

Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification†

Haitang Yang,a   Ying Li,a   Dingzhong Wang,b   Yong Liu,c   Wei Wei, ORCID logo *a   Yuanjian Zhang, ORCID logo a   Songqin Liu ORCID logo a  and  Peng Li*b  

* Corresponding authors

a Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
E-mail: weiw@seu.edu.cn
Fax: 86-25-52090618
Tel: 86-25-52090613

b Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, China

c College of Chemistry and Chemical Engineering, Henan University, Kaifeng, P. R. China

Abstract

A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which enable this QCM to be a sensitive biosensor for telomerase activity detection. The detection limit was as low as 37 cells per mL. The assay platform exhibited excellent selectivity.

Graphical abstract: Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification

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Article information

DOI
https://doi.org/10.1039/C9CC02610J
Article type
Communication
Submitted
04 Apr 2019
Accepted
25 Apr 2019
First published
26 Apr 2019

Chem. Commun., 2019,55, 5994-5997

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Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification

H. Yang, Y. Li, D. Wang, Y. Liu, W. Wei, Y. Zhang, S. Liu and P. Li, Chem. Commun., 2019, 55, 5994 DOI: 10.1039/C9CC02610J

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