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Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

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Abstract

Stylissatin A, an anti-inflammatory cyclic heptapeptide, and its derivatives potently inhibited the differentiation of preadipocytes and reduced triglyceride accumulation in mature adipocytes, with little cytotoxicity. Our studies might contribute to the development of leads for new anti-inflammatory and anti-obesity agents.

Graphical abstract: Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

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Publication details

The article was received on 01 Apr 2019, accepted on 10 Apr 2019 and first published on 11 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02517K
Citation: Chem. Commun., 2019, Advance Article

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    Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

    M. Zhang, T. Sunaba, Y. Sun, K. Sasaki, H. Isoda, H. Kigoshi and M. Kita, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02517K

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