Issue 38, 2019
From the journal:

Chemical Communications

Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes†

Menghua Zhang,ab   Taiki Sunaba,a   Yiting Sun,c   Kazunori Sasaki,ad   Hiroko Isoda,e   Hideo Kigoshi ORCID logo *a  and  Masaki Kita ORCID logo *ac  

* Corresponding authors

a Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8571, Japan
E-mail: kigoshi@chem.tsukuba.ac.jp

b PhD Program in Human Biology, School of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba 305-8577, Japan

c Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
E-mail: mkita@agr.nagoya-u.ac.jp

d Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8565, Japan

e Graduate School of Life and Environmental Sciences, and Alliance for Research on North Africa (ARENA), University of Tsukuba, Tsukuba 305-8577, Japan

Abstract

Stylissatin A, an anti-inflammatory cyclic heptapeptide, and its derivatives potently inhibited the differentiation of preadipocytes and reduced triglyceride accumulation in mature adipocytes, with little cytotoxicity. Our studies might contribute to the development of leads for new anti-inflammatory and anti-obesity agents.

Graphical abstract: Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

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Article information

DOI
https://doi.org/10.1039/C9CC02517K
Article type
Communication
Submitted
01 Apr 2019
Accepted
10 Apr 2019
First published
11 Apr 2019

Chem. Commun., 2019,55, 5471-5474

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Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

M. Zhang, T. Sunaba, Y. Sun, K. Sasaki, H. Isoda, H. Kigoshi and M. Kita, Chem. Commun., 2019, 55, 5471 DOI: 10.1039/C9CC02517K

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