Jump to main content
Jump to site search


Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone

Author affiliations

Abstract

Application of an oxidative amination reagent (di-tert-butyldiaziridinone) to the Ru3(CO)12-catalyzed ortho-selective CAr–H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential for this methodology. Mechanistic studies showed that the reaction process involves an octahedral ruthenium species, and the carbon monoxide ligand plays a crucial role in the C–H activation.

Graphical abstract: Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Mar 2019, accepted on 11 Apr 2019 and first published on 11 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02499A
Citation: Chem. Commun., 2019, Advance Article

  •   Request permissions

    Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone

    X. Gou, Y. Li, X. Wang, H. Liu, B. Zhang, J. Zhao, Z. Zhou and Y. Liang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02499A

Search articles by author

Spotlight

Advertisements