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Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

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Abstract

A series of phosphinate-containing rhodol and fluorescein dyes are disclosed. These new fluorophores increase the color palette of phosphinate-based xanthenes in the far-red spectral region. The new chemical functionality of these scaffolds is leveraged to produce a sensitive, no-wash imaging probe for cellular esterase activity. The reported phosphinate-containing dyes provide platforms for the further development of imaging probes and self-reporting delivery vehicles.

Graphical abstract: Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

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Publication details

The article was received on 31 Mar 2019, accepted on 25 Apr 2019 and first published on 29 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02492A
Chem. Commun., 2019, Advance Article

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    Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

    Y. Fang, G. N. Good, X. Zhou and C. I. Stains, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02492A

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