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Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

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Abstract

We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.

Graphical abstract: Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

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Publication details

The article was received on 27 Mar 2019, accepted on 24 Apr 2019 and first published on 25 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02388G
Chem. Commun., 2019, Advance Article

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    Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

    Y. Wei, J. Chen, B. Sun and P. Xu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02388G

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