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DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

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Abstract

DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner.

Graphical abstract: DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

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Publication details

The article was received on 27 Mar 2019, accepted on 11 Apr 2019 and first published on 12 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02365H
Citation: Chem. Commun., 2019, Advance Article

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    DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

    Y. Lin, L. Jiang, Y. Huang, Y. Yang, Y. He, C. Lu and H. Yang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02365H

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