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Iridium(III)-catalysed annulation of pyrazolidinones with propiolates: a facile route to pyrazolo[1,2-a] indazoles

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Abstract

A facile synthesis of various pyrazolo[1,2-a] indazoles from pyrazolidinones and propiolates via iridium(III)-catalysed C–H bond activation/subsequent [4+1] cyclization has been developed. The reaction proceeds smoothly under mild reaction conditions and propiolates act as a novel C1 synthon. This transformation represents a redox-neutral process, exhibits a highly regioselectivity, and tolerates various functional groups.

Graphical abstract: Iridium(iii)-catalysed annulation of pyrazolidinones with propiolates: a facile route to pyrazolo[1,2-a] indazoles

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Publication details

The article was received on 21 Mar 2019, accepted on 29 Apr 2019 and first published on 30 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02232E
Chem. Commun., 2019, Advance Article

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    Iridium(III)-catalysed annulation of pyrazolidinones with propiolates: a facile route to pyrazolo[1,2-a] indazoles

    Z. Yang, Z. Song, L. Jie, L. Wang and X. Cui, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02232E

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