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Issue 60, 2019

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

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Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Graphical abstract: Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Supplementary files

Article information


Submitted
20 Mar 2019
Accepted
20 Jun 2019
First published
20 Jun 2019

Chem. Commun., 2019,55, 8876-8879
Article type
Communication

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

D. Shetty, T. Skorjanc, M. A. Olson and A. Trabolsi, Chem. Commun., 2019, 55, 8876 DOI: 10.1039/C9CC02214G

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