Issue 42, 2019
From the journal:

Chemical Communications

Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells†

Joong Ho Moon, ORCID logo *a   Prakash Manandhar,a   Hooman Torabi,a   Md Rumum Rohman,a   Logesh Mathivathanan, ORCID logo a   Ka Hung Lee ORCID logo b  and  Stephan Irle ORCID logo b  

* Corresponding authors

a Department of Chemistry and Biochemistry, Biomolecular Sciences Institute, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA
E-mail: jmoon@fiu.edu

b Computational Sciences and Engineering Division & Chemical Sciences Division, Oak Ridge National Laboratory, POB 2008, Oak Ridge, TN 37831, USA

Abstract

Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid–flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.

Graphical abstract: Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

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Article information

DOI
https://doi.org/10.1039/C9CC02162K
Article type
Communication
Submitted
18 Mar 2019
Accepted
25 Apr 2019
First published
25 Apr 2019

Chem. Commun., 2019,55, 5930-5933

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Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

J. H. Moon, P. Manandhar, H. Torabi, M. R. Rohman, L. Mathivathanan, K. H. Lee and S. Irle, Chem. Commun., 2019, 55, 5930 DOI: 10.1039/C9CC02162K

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